Severe Persistent Bronchial Asthma: Literature Review

• Siti Maryam Iribaram

  Universitas Mandala Waluya

  Author

• Ulfa Ayu Pratiwi

  Universitas Mandala Waluya

  Author

• Adila Nur Arifah

  Universitas Mandala Waluya

  Author

• Nur Aebi

  Universitas Mandala Waluya

  Author

• Sepriani Nur Azizah

  Universitas Mandala Waluya

  Author

• Dinda Ayu Wulandari

  Universitas Mandala Waluya

  Author

• Khusnul Fadillah

  Universitas Mandala Waluya

  Author

• Dhija Almaida Banda

  Universitas Mandala Waluya

  Author

• Anisa Purnamasari

  Universitas Mandala Waluya

  Author

  https://orcid.org/0000-0002-1184-8416

• Alda Aprilia Veronica

  Universitas Mandala Waluya

  Author

Background: Severe persistent asthma is the most complex form of asthma, characterized by symptoms that cannot be optimally controlled despite the administration of high-dose standard therapy such as inhaled corticosteroids (ICS) combined with long-acting beta-2 agonists (LABA) and/or oral corticosteroids. This type of asthma significantly impacts the patient’s quality of life, increases the frequency of exacerbations, and leads to higher healthcare costs.

Purpose: To evaluate the impact of combination therapy and biological therapy approaches on key clinical outcomes such as reduction in exacerbations, improvement in quality of life, and decreased use of systemic corticosteroids.

Methods: Articles were collected from the PubMed, ScienceDirect, and other peer-reviewed journal databases, with a publication range from 2021 to 2025.

Results: The search yielded 10 articles that met the specified criteria and keywords. Biologic therapy has been proven effective in reducing exacerbations, improving lung function, and decreasing dependence on systemic corticosteroids.

Conclusion: The importance of early intervention, accurate diagnostic approaches, and careful use of biologic therapy highlights the need for timely detection and treatment to prevent long-term damage.

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Jafari, M., Sobhani, M., Eftekhari, K., Malekiantaghi, A., Gharagozlou, M., & Shafiei, A. (2023). The Effect of Oral Montelukast in Controlling Asthma Attacks in Children: A Randomized Double-blind Placebo Control Study. Iranian Journal of Allergy, Asthma and Immunology, 22(5), 413–419. https://doi.org/10.18502/ijaai.v22i5.13990.

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Savin, I. A., Zenkova, M. A., & Sen’kova, A. V. (2023). Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process. International Journal of Molecular Sciences, 24(22). https://doi.org/10.3390/ijms242216042.

Thomas, D., McDonald, V. M., Pavord, I. D., & Gibson, P. G. (2022). Asthma remission- what is it and how can it be achieved? European Respiratory Journal, 60(5). https://doi.org/10.1183/13993003.02583-2021.

Yamaguchi, M., Nishimura, Y., Takumi, Y., Hayashi, N., Sakamoto, K., & Tohda, Y. (2024). Real-World Safety and Effectiveness of Benralizumab in Japanese Patients with Severe Asthma: A Multicenter Prospective Observational Study. Journal of Asthma and Allergy, 17, 45–60. https://doi.org/10.2147/JAA.S432695.

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